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Polyclonal B lymphocytosis


This rare, little known and recently discovered (1982) affects almost exclusively young women Great Smoky (20 pack-years).
There is a moderate lymphocytosis with a polyclonal increase in B lymphocytes
A HLA DR7 is associated almost constantly (see HLA AND CERTAIN DISEASES
and an increase in IgM (see SERUM IGM) and a particular cytogenetic anomaly. the isochromosome 3q, sometimes with trisomy 3 in about two-thirds of parents.
A large karyotypic instability (see KARYOTYPE) is noted and a syndrome of premature condensation of chromatin is often observed.
The role of tobacco remains unknown but lymphocytosis decreases during shutdown.
Genetic abnormalities persist.

This disease is considered benign but a transformation is possible in non-Hodgkin lymphoma which justifies prolonged haematological monitoring (see LYMPHOMA).

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Author: Mohammad
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