Moderate or no alcohol consumption associated with risk of mild cognitive impairment
,
Of alcohol consumption at zero
frequency, or otherwise reach several times a month, in mid-life, seems
associated with a higher risk of developing mild cognitive decline later
compared to a slight risk consumption, suggests a study Swedish- Finnish.
This work goes against the findings
of a study, published in the "American Journal of Epidemiology",
suggesting that drinkers show better cognitive performance. They abound,
however, in line with previous studies suggesting that mild to moderate alcohol
consumption would have a protective effect on the brain, compared to a total
abstinence or heavy drinking.
Tiia Anttila, of the Karolinska
Institute in Stockholm, and colleagues observed 1,018 men and women aged 65 to
79 years, including alcohol consumption was estimated on average 23 years ago,
and whose physical and mental health had been regularly assessed between these
two dates.
Participants did not consume alcohol
at all, as well as those consuming alcohol frequently (several times a month)
in the middle of their lives have a two times higher risk of mild cognitive
impairment after age 65, compared to participants drank some alcohol (less than
once per month).
The risk of dementia is in turn
influenced by the presence of a particular form of the gene coding for
apolipoprotein E, 4 allele, already known as a risk factor for dementia because
it predisposes to the disease of Alzheimer.
Thus, only the carriers of the ApoE4
allele have an increased risk of dementia with increasing alcohol consumption,
suggesting that this gene enhances the harmful effects of alcohol on the brain.
Compared to non-carriers who never
drink, the risk for carriers of the ApoE4 who never drink was not different
Wearing the non this gene does not
appear to affect the risk of cognitive decline weighing on people who never
drink alcohol. However, this risk is multiplied by 2.3 for carriers of the
ApoE4 allele rarely drank and 3.6 for those drinking more frequently, compared
to non-carriers of the gene with a similar alcohol.
In the latter, the alcohol did not
appear related to the risk of dementia.
Given the adverse effects of alcohol
depend on the amount consumed, the authors warn people that increase their
alcohol consumption hoping to protect the appearance of dementia that this
behavior can lead to the opposite effect from those anticipated.
Author: Mohammad
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