their heavily modified activity.

For example, theophylline: for the same dose, blood concentrations obtained are lower in smokers than in non-smokers. Its effect is shortened bronchodilator in smokers versus non-smokers.

The BETA-BLOCKERS have a hypotensive action significantly reduced.

The anti-ulcer, insulin should be prescribed at higher doses for smokers to get the same results.

Analgesics, anti-inflammatory drugs, some psychotropic medications and certain diuretics have any action in smokers.

Tobacco decreases the action of certain drugs such as chlorpromazine (the largactil) valium.

By cons, side effects of certain subtances are increased by smoking:

- The Tobacco and drugs

Among current smokers thérapeuthiques the consequences can be significant, and some drugs have hormonal (see PILL)

- General ANAESTHETICS

- Prostaglandins.

If we add that the action of alcohol and certain dietary habits modify the action of drugs, it is clear that smoking also adds its adverse effects in therapeutic action.